Key Features and Values
– Highly sensitive assay based on clinical data
– Simplified assay procedure with all reagents ready to use
– Supported by comprehensive panel of markers for differentiation between classical and alternative complement activation
Product Description
Immunoenzymatic colorimetric method for the quantitative determination of Circulating ImmuneComplex C3d (CIC C3d) concentration in human serum or plasma. CIC C3d ELISA kit is intended for laboratory use only.
Scientific Description
The importance of the immunocomplex (CIC) and their relation with several diseases have been object of investigations for many years. The enstablishment of immunocomplex is a normal protecting process of the immune system. The circulating immunocomplex are removed from the circulation by means of various cellular, biochemical and enzymatic processes. Key of elimination of many CIC is the activation of the classic way of the complement.
In some diseases, of difficult understanding, the immunocomplex can begin the damaging of tissue and organs. In this case the activation of the complement can lead to the anafilotoxine production, stimulation of leukocyte and activation of macrophage and other cells.
In some diseases, of difficult understanding, the immunocomplex can begin the damaging of tissue and organs. In this case the activation of the complement can lead to the anafilotoxine production, stimulation of leukocyte and activation of macrophage and other cells.
In some cases of glomerulonephritis, in which the immunocomplex fix to the cellular membranes, it has the destruction of the tissue. Circulating immuno-complexes (CIC) are present in many individuals affections from systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), especially in those affections from vasculitis complications. There are many tests for the determination of CIC, included the test of precipitation with PEG, radial immunodiffusion and cellular tests like the test of Ray cell.
Currently there is no single procedure to determine all types of immunocomplex; there are however, some test to determine fragments of the complex (Es. C1q and C3d), that have an important role in diagnosis.