TSH Receptors Ab

Key Features and Values

– Same sample type can be used across all assays to simplify inclusion into routine serology work-up
– Ready to use reagents reduces hands-on time for assay preparation
– Long shelf life cost-effective solution by reducing wastage due to expired kits
– Suitable for inclusion on automated plate systems simplifies scale-up of test volume
– Supported by a complete panel of assays for supporting treatment monitoring of several forms of hormonal dysfunctions

Product Description

TSH Receptor Ab (TRAb) ELISA kit is intended for use by professional persons only for the quantitative determination of thyrotropin receptor autoantibodies in human serum.
TSH Receptor Ab kit is intended for laboratory use only.

Scientific Description

Hyperthyroidism is a disease that produces an increase in circulating levels of thyroid hormones.  In some cases, as in Graves’ disease is caused by autoantibodies against the TSH receptor (TSHr).  Autoantibodies mimic the effect of TSH on the thyroid gland causing a rise in blood levels of T3 and T4.  The determination of these autoantibodies (TRAb) may be useful for the diagnosis of the disease and its treatment.  The main treatment for Graves’ disease is represented by use of antithyroid drugs (propylthiouracil or methimazole), I131 and surgery.  The dosage of TRAb is therefore useful in the course or at the end of therapy.

Publications

1. J. Bolton et al Measurement of thyroid stimulating hormone receptor autoantibodies by ELISA Clin. Chem 1999 45: 2285-2287
2. K Kamijo TSH receptor antibody measurement in patients with various thyrotoxicosis and Hashimoto’s thyroiditis: a comparison of two twostep assays, coated plate ELISA using porcine TSH receptor and coated tube radioassay using human recombinant TSH receptor Endocrine Journal 2003 50:113-116
3. B. Rees Smith et al A new assay for thyrotropin receptor autoantibodies Thyroid 2004 14: 830-835

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Code: DKO085
Clinical Area:
Incubation: 120+25+20 min
Classification: IVD, CE
Number of Tests: 96
Sample Type: Serum / Plasma
Sample Volume: 75 μL
Assay Range: 1 - 40 U/L