Anti-TG

Key Features and Values

– Same sample type can be used across all assays to simplify inclusion into routine serology work-up
– Ready to use reagents reduces hands-on time for assay preparation
– Long shelf life cost-effective solution by reducing wastage due to expired kits
– Suitable for inclusion on automated plate systems simplifies scale-up of test volume
– Supported by a complete panel of assays for supporting treatment monitoring of several forms of hormonal dysfunctions

Product Description

Indirect Immunoenzymatic colorimetric method for the quantitative determination of Anti-Tg concentration in human serum or plasma. Anti TG ELISA kit is intended for laboratory use only.

Scientific Description

Thyroglobulin (Tg) is a protein produced by and used entirely within the thyroid gland.  Thyroglobulin is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3).  Thyroglobulin synthesis is stimulated at the transcriptional level by thyroid-stimulating hormone (TSH) Thyroglobulin (Tg) is a well-known target for autoantibodies occurring in thyroid autoimmunity (Graves’ disease and Hashimoto’s thyroiditis).  Anti-Tg antibodies mostly belong to the IgG class.  Low to moderate levels of anti-Tg antibodies can be found in sera of other autoimmune patients (eg systemic lupus erythematosus or Sjogren syndrome).  In some cases anti-Tg positive sera may show negativity for other types of anti-thyroid antibodies – anti-TPO.  Therefore, combined determination of both types of antithyroid antibodies (anti-TPO + anti-Tg) provides most sensitive laboratory diagnostic tool for thyroid autoimmunity.  Separately from autoimmunity, anti-Tg antibodies may develop in patients suffering from thyroid cancer.
High level of anti-Tg in such patients may interfere with correct determination of serum thyroglobulin, which serves as tumour marker for therapy control in this group of patients.

Publications

1. Volpè R., CRC Press , (1990)
2. Volpè R., Clin. Chem. 40 2132 (1994)
3. Beever K., Clin. Chem. 35 1949-54 (1989)
4. Mat Clin. Chem. 40 2128 (1994)
5. Chiavato L., Autoimmunity 10, 319-31 (1991)
6. Degroot LJ, Thyroperoxidase Thyroid Autoimmunity 207:177 – 182 (1990)

Download
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Code: DKO115
Clinical Area:
Incubation: 30+30+15 min
Classification: IVD, CE
Number of Tests: 96
Sample Type: Serum/Plasma
Sample Volume: 10 µL (1:100 predilution)
Assay Range: 2 - 128 AU/mL