Key Features and Values
- Same sample type can be used across all assays to simplify inclusion into routine serology work-up
- Ready to use reagents reduces hands-on time for assay preparation
- Long shelf life cost-effective solution by reducing wastage due to expired kits
- Suitable for inclusion on automated plate systems simplifies scale-up of test volume
- Supported by a complete panel of assays for supporting treatment monitoring of several forms of hormonal dysfunctions
Product Description
Competitive immunoenzymatic colorimetric method for the quantitative determination of Dehydro-epiandrosterone sulfate (DHEA-S) concentration in human serum or plasma.
DHEA-S ELISA kit is intended for laboratory use only.
Scientific Description
Dehydroepiandrosterone sulfate (DHEA-S), is a natural steroid hormone found atop of the kidneys in the human body. DHEA-S derived from enzymatic conversion of DHEA in adrenal and extradrenal tissues. DHEA-S is also produced in the gonads, adipose tissue and the brain. It is the most abundant hormone in the human body and it is precursor of all sex steroids.
As most DHEA-S is produced by the zona reticularis of the adrenal gland, it is argued that there is a role in the immune and stress response. DHEA-S may have more biologic roles. Its production in the brain suggests that it also has a role as a neurosteroid. Measurement of serum DHEA-S is a useful marker of adrenal androgen synthesis. Abnormally low levels have been reported in hypoadrenalism, while elevated levels occur in several conditions, e.g. virilising adrenal adenoma and carcinoma, 21-hydroxylase and 3β-hydroxysteroid dehydrogenase deficiencies and in some cases of female hirsutism.
Women with polycystic ovarian syndrome (PCOS) tend to have normal or mildly elevated levels of DHEA-S. As very little DHEA-S is produced by the gonads, measurement of DHEA-S levels may aid in the localisation of androgen source in virilising conditions. DHEA-S levels show no diurnal variation.
Publications
1. Abraham G.E., et al Obstet. Gynecol., 47 (4), 395 (1976)
2. Granoff A.B. et al Obstet. Gynecol., 53 (1), 111 (1979)
3. Hopper B.R.et al J. Clinic. Endocrin. Metab. 40 (3), 458 (1975)
4. Winter J.S.D, et al Clinic. Obstetic and Gynecol., 21 (1), 67 (1978)
5. Cristina Mihaela Ghiciuc C.M et al., Neuroendocrinol Lett 2011; 32(4):475–480