Key Features and Values
- Same sample type can be used across all assays to simplify inclusion into routine serology work-up
- Ready to use reagents reduces hands-on time for assay preparation
- Long shelf life cost-effective solution by reducing wastage due to expired kits
- Suitable for inclusion on automated plate systems simplifies scale-up of test volume
- Supported by a complete panel of assays for supporting treatment monitoring of several forms of hormonal dysfunctions
Product Description
Competitive immunoenzymatic colorimetric method for quantitative determination of Progesterone concentration in human serum or plasma. Progesterone ELISA kit is intended for laboratory use only.
Scientific Description
Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. Progesterone is the major naturally occurring human progestagen. Progesterone is important for aldosterone (mineralocorticoid) synthesis, as 17-hydroxyprogesterone is for cortisol (glucocorticoid). Progesterone levels are relatively low in children and postmenopausal women. Adult males have levels similar to those in women during the follicular phase of the menstrual cycle.
In women, progesterone levels are relatively low during the preovulatory phase of the menstrual cycle, rise after ovulation, and are elevated during the luteal phase. If pregnancy occurs, progesterone levels are maintained at luteal levels initially. After delivery of the placenta and during lactation, progesterone levels are very low. The fall in progesterone levels following delivery is one of the triggers for milk production.
Progesterone is produced in the adrenal glands, the gonads (specifically after ovulation in the corpus luteum), the brain, and, during pregnancy, in the placenta. Progesterone converts the endometrium to its secretory stage to prepare the uterus for implantation. If pregnancy does not occur, progesterone levels will decrease, leading, in the human, to menstruation.
Progesterone belongs to the group of neurosteroids that are found in high concentrations in certain areas in the brain and are synthesised there. Neurosteroids affect synaptic functioning, are neuroprotective and affect myelinisation. Progesterone has multiple effects outside of the reproductive system. Progesterone is thermogenic, it reduces spasm and relaxes smooth muscle. Bronchi are widened and mucus regulated. Progesterone acts as an anti-inflammatory agent and regulates the immune response. Progesterone also assists in thyroid function, in bone building by osteoblasts. Measurement of serum progesterone concentrations have been used in evaluating ovarian function.